Research Services

A proper literature search is integral to defining your research question and designing your study.

If your research question is too broad, you will have difficulty designing a focused study and collecting data to answer your hypothesis. If it’s too narrow, you will have difficulty finding the appropriate participants.

If you need to create a proposal to apply for funding, and the funding agency does not have its own template, you can use the CHÉOS template.

CIHR is the primary source of federal funds for health research in Canada; other suggestions for funding include disease-related foundations, industry partners, and local research organizations.

While you can use your proposal as a template for your protocol, a proposal is written to only obtain support for your study. A study protocol contains detailed instructions on how the study will be conducted and includes information to meet regulatory requirements.

There can be a significant overlap between Quality Improvement (QI) and research. Generally, QI is conducted to improve or measure the effectiveness of a program or service; research is a more structured investigation designed to contribute to generalizable knowledge.

Health Canada Clinical Trial Applications (CTAs), ethics submission, contract review, and administrative approvals can often be undertaken simultaneously. Check with your local institution’s research administration for more information.

Approvals required for a clinical research project can include Health Canada, ethics, and organizational approvals, as well as trial registration.

Any contract or agreement necessary to start your research study should be run through your contracts office. This includes confidentiality agreements, sub-site agreements, or industry clinical trial agreements, among others.

All Health Canada regulated clinical trials require maintenance of essential documents. It’s strongly recommended that all non-regulated research studies maintain these documents to comply with Good Clinical Practice (GCP) guidelines.

Most Research Ethics Boards require that study team members complete basic training in research ethics, as well as specific training related to the study protocol, like transportation of dangerous goods.

You may wish to conduct a needs assessment in advance to determine your human resource requirements to perform the study. For example, how much work will this study entail and what sort of training is required? For Health Canada regulated clinical trials, you are required to conduct this needs assessment prior to hiring staff.

For Health Canada regulated clinical trials, you are required to provide oversight on the study to ensure it is conducted in accordance with the protocol, SOPs, GCP, and local requirements.

Recruitment and participant retention can be the most challenging aspect of any clinical research study. A potential study participant may meet all the inclusion/exclusion criteria, but find the time commitment too onerous, the study too complicated, or be worried about how participation may affect their disease. You should have a realistic recruitment plan in place: site databases, social media, and print advertising are just some suggested recruitment strategies. Note that any recruitment materials must be approved by the REB.

Once the study is complete, you will need to contact a biostatistician (preferably the one who created the statistical section in the protocol, or the statistical analysis plan in regulated studies) to analyze the data. CHÉOS provides one hour of free consultation as well as statistical analysis services at a reasonable cost.

If you decide to publish a manuscript, each journal has its own format and guidelines for manuscript preparation. For general rules, the EQUAtor website has a searchable database for reporting guidelines.

If your study is a clinical trial regulated by Health Canada, you are required by Health Canada to retain study documents for 25 years after trial completion. UBC now offers records management/storage services at a reasonable cost.

There are many other sources of information on designing and executing a research project.