Principal Investigators: Drs. Krishnan Ramanathan and James Abel
Page template : single-portfolio.php Search terms : Sort : Page : 0
The prevalence of diabetes mellitus (DM) in British Columbia was 7.4% in 2010 and this number is expected to increase to 10.3% by 2020. Patients with DM are prone to a diffuse and rapidly progressive form of atherosclerosis, which increases their likelihood of requiring revascularization. Selection of the optimal myocardial revascularization strategy for patients with DM and coronary artery disease (CAD) is crucial to reducing the high rate of thrombotic complications and improving quality of life outcomes in high-risk patients.
In 2012, the results of the Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multi-vessel Disease (FREEDOM) trial demonstrated superiority of coronary artery bypass grafting (CABG) over percutaneous coronary intervention (PCI) using drug eluting stents during a 5-year follow up period. However, the real world applicability of the FREEDOM trial results is uncertain given the restrictive nature of clinical studies. Furthermore, the long-term (i.e. > 5-years) outcome of these procedures in a chronic disease setting is unknown.
This is an analysis of retrospectively collected, linked administrative and clinical data. Patient risk factors, coronary anatomy, coronary revascularization strategy and subsequent revascularization data will be obtained from the Cardiac Services BC Heart Information System (HEARTis). Details of clinical events (myocardial infarction, congestive heart failure, arrhythmias and stroke) and all-cause mortality will be requested via Population Data BC from the Discharge Abstract Database and the Vital Statistics Deaths File, respectively. Analyses will be performed at the BC Centre for Improved Cardiovascular Health.
As the prevalence of DM continues to increase in epidemic proportions, further knowledge is needed in the management of CAD. In BC, the availability of HEARTis, a standardized registry for all diagnostic and interventional catheterization and open heart surgery procedures, offers a unique opportunity to further extend the findings from the international FREEDOM trial.
Reference: Farkouh ME, et al. for the FREEDOM Trial Investigators. Strategies for multivessel revascularization in patients with diabetes. N Engl J Med. 2012 Dec 20;367(25):2375-84. Epub 2012 Nov 4.
Surgical Versus Percutaneous Coronary Revascularization in Patients With Diabetes and Acute Coronary Syndromes. Ramanathan K, Abel JG, Park JE, Fung A, Mathew V, Taylor CM, Mancini GBJ, Gao M, Ding L, Verma S, Humphries KH, Farkouh ME. J Am Coll Cardiol. 2017 Dec 19;70(24):2995-3006. doi: 10.1016/j.jacc.2017.10.029.
HeartHub.ca – An online information resource for patients, by patients