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Biostatistics

Biostatistics involves the development and application of statistical principles to the design, analysis, and execution of health research.

Program Head: Dr. Hubert Wong

The Biostatistics Program at CHÉOS provides support to researchers for all statistical needs in the design and analysis of research studies. Our team of biostatisticians have broad expertise designing and analyzing clinical trials, developing clinical prediction models, and applying causal inference methods to observational data. Areas of specific expertise include the design of Bayesian adaptive randomized trials and causal inference methods for complex longitudinal and time-to-event data.

Examples of services we provide are: developing study methodology (e.g. quantifying research objectives, sample size calculation, statistical analysis plan), data analysis, interpretation of results, drafting of manuscripts, and responding to reviewer comments. In addition, CHÉOS biostatisticians engage in the development of new statistical approaches and methodologies.

Examples of work conducted by our Biostatistics Program include:

Design and Analysis of Randomized Controlled Trials

  • Optimal duration of risperidone or olanzapine adjunctive therapy to mood stabilizer following remission of a manic episode: A CANMAT randomized double-blind trial (Publication Link)
  • Development of Bayesian adaptive trial design methodology for structured multi-arm comparisons (e.g. factorial designs)

Please visit our Clinical Trials Program page for more information.

Development of Clinical Prediction Models

  • Development and validation of a prediction rule for early discharge of low-risk emergency department patients with potential ischemic chest pain (Publication Link)

Design and Analysis of Observational Studies

  • Natural history of cartilage damage and osteoarthritis progression on magnetic resonance imaging in a population-based cohort with knee pain (Publication Link)
  • Characterization of myocardial repolarization reserve in adolescent females with anorexia nervosa (Publication Link)

Analysis of Clinical and Administrative Health Databases

  • Attributable length of stay and mortality of major bleeding as a complication of therapeutic anticoagulation in the intensive care unit (Publication Link)
  • Association between source of infection and hospital mortality in patients who have septic shock (Publication Link)
  • Intermediate-term results of total ankle replacement and ankle arthrodesis: A COFAS Multicenter Study (Publication Link)
  • Is the road to mental health paved with good incentives? Estimating the population impact of physician incentives on mental health care using linked administrative data (Publication Link)
  • The impact of cost sharing of prescription drug expenditures on health care utilization by the elderly: Own- and cross-price elasticities (Publication Link)

Health research in the heart of Vancouver