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Work in Progress Seminar: Dr. Wenjia Chen

September 11, 2019 @ 12:00 pm – 1:00 pm
Cullen Family Lecture Theatre (SPH 1477)
St. Paul's Hospital

Please note: This talk is taking place at the Cullen Family Lecture Theatre (SPH 1477).

Wenjia Chen, MPH, PhD

Postdoctoral Research Fellow, Collaboration for Outcomes Research and Evaluation (CORE), UBC

An individualized prediction model for long-term lung function trajectory and risk of COPD in the general population

Chronic obstructive pulmonary disease (COPD) is often diagnosed late, leading to high exacerbation rate and increased comorbidities and costs. Prediction of future lung function will enable early identification of individuals at high risk of developing COPD, but the trajectory of lung function decline greatly varies among individuals. For patients who have been formally diagnosed with COPD, multiple prediction tools are available for prognostic purposes. For the general population, however, there are few validated predictive tools to provide prognostic information on which individuals will (or will not) develop COPD. Using 25-year data from the well-conducted Framingham Offspring cohort, we developed a prediction model of lung function trajectory and risk of airflow limitation in the general population. Essential predictors were selected using machine learning algorithms. The prediction was individualized, conditional on previous lung function history. This model was validated in two large, independent multi-center cohorts. We implemented this model in a freely accessible Web-based application, which allows prediction based on flexible sets of predictors. This individualized predictor can be used to identify individuals at higher risk of COPD who can be targeted for preventive therapies.

Work in Progress (WiP) presentations take place at St. Paul’s Hospital on alternating Wednesdays from 12:00–1:00 PM. These seminars provide investigators with an opportunity to present ongoing research, obtain feedback from colleagues and peers, and make new connections for their projects. Talks are open, and a light lunch is served.

View the 2019–2020 WiP schedule.

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