1081 Burrard Street
Karin Humphries, D.Sc
Associate Professor, Division of Cardiology, Department of Medicine, UBC
Scientific Director, B.C. Centre for Improved Cardiovascular Health
Under-diagnosis and under-treatment of women with CAD: is hs-cTn a means to an end?
In patients with suspected acute coronary syndromes, females are significantly less likely to undergo investigations or receive evidence-based treatments, and they consistently have worse outcomes than males. Several reasons for this have been suggested, including different symptoms at presentation, greater delay in presenting for care, and the use of diagnostic tools that do not take sex into account.
Cardiac troponin (cTn) is a biomarker used in the diagnosis of myocardial infarction/injury. A rise and/or fall of hs-cTn, in addition to at least one level of hs-cTn above the 99th percentile based on a healthy population (which serves as the cut-point), is a key component in this diagnosis. With the introduction of high-sensitivity (hs) cTn, it is now well documented that the distribution, and hence the 99th percentile cut-point, varies by sex, with females having a much lower cut-point than males. However, in current practice, a single cut-point based on the 99th percentile of the overall population is standard practice.
A trial to evaluate the diagnostic and prognostic implications of using a lower, sex-specific cut-point in women will be described and discussed from the perspective of closing the gap of under-diagnosis and under-treatment in females presenting with ischemic heart disease.
Work in Progress (WiP) presentations take place at St. Paul’s Hospital in the Hurlburt Auditorium on alternating Wednesdays from 12:00–1:00 PM. These seminars provide investigators with an opportunity to present ongoing research, obtain feedback from colleagues and peers, and make new connections for their projects. Talks are open, and a light lunch is served.