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Going Beyond Sensitivity and Specificity to Replace the TB Skin Test

April 22, 2015 @ 12:00 pm – 1:00 pm
Hurlburt Auditorium, St. Paul's Hospital
1081 Burrard Street

Daphne Ling, PhD

Postdoctoral Fellow, CHÉOS and Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, UBC

Abstract: Management of any disease relies on diagnosis as the crucial first step.  For over a century, diagnosis of latent tuberculosis (TB) has relied on the tuberculin skin test, which has several limitations.  Most studies evaluating newer tests have only reported on their accuracy, which is insufficient for policy recommendations and guideline development.

This talk will discuss evaluating the added value of new tests or biomarkers using a probabilistic and more holistic framework.  Topics will include the use of: 1) multivariable prediction models for risk stratification 2) pragmatic studies to assess clinical utility in routine practice and 3) propensity scores within a diagnostic and health systems context.

This talk is open and will include a light lunch.

Work in Progress Seminar April 22: Going Beyond Sensitivity, Specificity to Replace the TB Skin Test by Cheosnews on Mixcloud

Health research in the heart of Vancouver